Exophiala dermatitidis: Key issues of an opportunistic fungal pathogen

Exophiala dermatitidis: Key issues of an opportunistic fungal pathogen

Blog Article

The black yeast Exophiala dermatitidis is an opportunistic pathogen, jolly rancher filled gummies causing phaeohyphomycosis in immunosuppressed patients, chromoblastomycosis and fatal infections of the central nervous system in otherwise healthy Asian patients.In addition, it is also regularly isolated from respiratory samples from cystic fibrosis patients, with rates varying between 1% and 19%.Melanin, as part of the cell wall of black yeasts, is one major factor known contributing to the pathogenicity of E.dermatitidis and increased resistance against host defense and anti-infective therapeutics.

Further virulence factors, e.g.the capability to adhere to surfaces and to form biofilm were reported.A better understanding of the pathogenicity of E.

dermatitidis is essential for the development of novel preventive and therapeutic strategies.In this review, the current knowledge of E.dermatitidis prevalence, clinical importance, diagnosis, microbiological characteristics, virulence attributes, susceptibility, and resistances as well as deus gorras therapeutically strategies are discussed.